Figure 4.

Relationships between pathological oscillatory neuronal slowing, regional amyloid-β uptake and cognition in patients on the Alzheimer’s disease spectrum. Surface maps on the top left indicate the mean vertex-wise uptake of amyloid-β (Aβ), measured by quantitative ¹⁸F florbetapir PET, in SUVRs. The spatial correspondence between this regional amyloid-β uptake and the pathological oscillatory slowing effect is indicated by the plot on the top right, where the individual model fit (with corresponding confidence intervals) between these measures over all cortical vertices is indicated for each patient by the coloured fit lines and the overall model fit (again with confidence intervals) is overlaid in black. The comparable plot on the bottom left indicates the significant interaction effect of clinical determination on the POSI–amyloid-β relationship. The plot on the bottom right indicates the impact of the magnitude of this pathological relationship (x-axis) on attentional abilities (y-axis), with the partial correlation coefficient, line-of-best-fit and corresponding confidence intervals overlaid. Note that more negative values on the x-axis indicate a stronger pathological relationship between regional amyloid-β burden and neural slowing. For all plots, clinical determination is indicated by the colour of each data-point/fit line (aMCI = blue, probable Alzheimer’s disease = red).