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. 2022 Jun 20;7(7):986–1000. doi: 10.1038/s41564-022-01152-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (A) Comparison of LC-MS/MS fragmentation patterns of ΔBT_1525 BT-derived phosphatidylinositol phosphate (PIP-DAG) with the synthetic standard, PI(3)P 18:1/18:1. (B) LC-MS/MS fragmentation patterns of lipid structures present in iSPT BT at 100 ng/mL aTC induction, including phosphoinositol dihydroceramide (PI-DHC) lipids (PI-DHC 34:0(OH), PI-DHC 35:0(OH), PI-DHC 36:0(OH)), PI-DAG 30:0, and PE-DHC 36:0(OH). Loss of the phosphoinositol head group is indicated at mass 259. Fragments characteristic for lipids with phosphoinositol-based headgroups are in red; those for phosphoethanolamine-based headgroups are in blue. Branching patterns of DHC-based lipids are predicted.