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The average (A) NMSE, (B) SSIM, (C) FWHM and (D) CV measurements for different denoising methods for the clinical dataset. Error bars indicate the standard deviation of the respective indices for 20 patients. *, P<0.05; **, P<0.01; ***, P<0.001. NMSE, normalized mean square error; SSIM, structural similarity index; FWHM, full-width-at-half-maximum; CV, coefficient of variation; CAE, convolutional auto encoder; GAN, generative adversarial network.
