Clinical MP SPECT images with various noise levels of (A) a sample normal patient (male, age =49 years, BMI =25.5 kg/m2) and (B) a sample patient (male, age =76 years, BMI =19.2 kg/m2) with a known cardiac defect (green arrow) processed under different denoising methods. CAE, convolutional auto encoder; GAN, generative adversarial network; MP, myocardial perfusion; BMI, body mass index.