Table 2.
Surgical outcomes
| Intention to treat | Per protocol | |||||
|---|---|---|---|---|---|---|
| Intervention N = 157 (%) |
Control N = 170 (%) |
P-value | Intervention N = 139 (%) |
Control N = 158 (%) |
P-value | |
| Surgical outcome | ||||||
| Complete | 119 (75.8) | 115 (67.6) | 0.001 | 119 (85.6) | 113 (71.5) | 0.002 |
| Optimal | 12 (7.6) | 38 (22.4) | 12 (8.6) | 38 (24.1) | ||
| Suboptimal | 8 (5.1) | 8 (4.7) | 8 (5.8) | 7 (4.4) | ||
| Unresectable | 18 (11.5) | 9 (5.3) | - | - | ||
| Complete cytoreductive surgery YES | 119 (75.8) | 115 (67.6) | 0.131 | 119 (85.6) | 113 (71.5) | 0.005 |
| Start of surgery | ||||||
| Primary CRS | 20 (12.7) | 25 (14.7) | 0.722 | 20 (14.4) | 22 (13.9) | 1 |
| Interval CRS | 137 (87.3) | 145 (85.3) | 119 (85.6) | 136 (86.1) | ||
| Operative time (min) | ||||||
| Mean [SD] | 236 [126] | 222 [110] | 0.326 | 254 [121] | 230 [109] | 0.084 |
| Median [min, max] | 210 [29, 671] | 194 [48, 595] | 234 [45, 671] | 202 [65, 595] | ||
| Missing | 6 (3.8) | 4 (2.4) | 5 (3.6) | 3 (1.9) | ||
| Abdominal drain | 35 (22.3) | 50 (29.4) | 0.259 | 35 (25.2) | 49 (31.0) | 0.263 |
| Blood loss (ml) | ||||||
| Mean [SD] | 923 [801] | 956 [801] | 0.712 | 1020 [803] | 995 [805] | 0.827 |
| Median [min, max] | 700 [0, 4300] | 845 [0, 6000] | 800 [50.0, 4300] | 875 [0, 6000] | ||
| Missing | 4 (2.5) | 1 (0.6) | 4 (2.9) | 0 | ||
| Transfusion during surgery | 41 (26.1) | 45 (26.5) | 0.877 | 41 (29.5) | 45 (28.5) | 0.961 |
| Colostomy | 9 (5.7) | 20 (11.8) | 0.092 | 9 (6.5) | 20 (12.7) | 0.169 |
| Intensive care postoperative | 34 (21.7) | 40 (23.5) | 0.785 | 33 (23.7) | 39 (24.7) | 0.957 |
| Intensive care (days) | ||||||
| Mean [SD] | 1.9 (1.9) | 1.6 (0.9) | 0.339 | 1.9 [1.9] | 1.6 [0.9] | 0.378 |
| Median [min, max] | 1.0 [1,11] | 1.0 [1,5] | 1.0 [1,11] | 1.0 [1,5] | ||
| Hospitalization (days) | ||||||
| Mean [SD] | 8.7 [6.5] | 7.9 [6.4] | 0.221 | 9.1 [6.7] | 8.1 [6.6] | 0.175 |
| Median [min, max] | 6.5 [2, 35] | 6.0 [2, 51] | 7.0 [2, 35] | 6.0 [3, 51] | ||
| Missing | 3 (1.9) | 0 | 3 (2.2) | 0 | ||
| Discharge | ||||||
| Home without nursing care | 100 (63.7) | 110 (64.7) | 0.955 | 86 (61.9) | 101 (63.9) | 0.975 |
| Home with nursing care | 34 (21.7) | 39 (22.9) | 31 (22.3) | 38 (24.1) | ||
| Nursing home | 4 (2.5) | 3 (1.8) | 3 (2.2) | 3 (1.9) | ||
| Rehabilitation center | 2 (1.3) | 2 (1.2) | 2 (1.4) | 2 (1.3) | ||
| Hotel providing nursing care | 9 (5.7) | 12 (7.1) | 9 (6.5) | 10 (6.3) | ||
| Hospice | 1 (0.6) | 0 | 1 (0.7) | 0 | ||
| Death | 0 | 0 | 0 | 0 | ||
CRS cytoreductive surgery