Table 2.
Post-treatment levels of vascular and cerebrovascular function. Values for cognitive performance are presented as mean rank scores across subtests. Cognitive function scores are presented as model adjusted, mean rank scores within each outcome domain. Data for both baseline and posttreatment estimates were derived from the full, fitted regression models and may therefore differ slightly from raw values provided in Table 1.
| Outcome Measure (Primary / Secondary) |
C-LIFE | SEPA | ||
|---|---|---|---|---|
| Baseline | Post-Treatment | Baseline | Post-Treatment | |
| Executive Function / Learning, mean rank score (Primary)* | 64.2 (60.5, 67.8) | 66.8 (64.2, 69.4) | 65.1 (60.3, 70.0) | 62.6 (58.6, 66.6) |
| Memory, mean rank score (Secondary) | 63.9 (58.6, 69.3) | 66.3 (62.5, 70.0) | 66.1 (58.8, 73.3) | 65.5 (59.7, 71.2) |
| Processing Speed, mean rank score (Secondary) | 65.8 (60.8, 70.8) | 66.0 (63.9, 68.2) | 63.2 (56.4, 70.0) | 66.7 (63.4, 70.0) |
| Vascular and Microvascular Function | ||||
| Flow Mediated Dilation, % (Primary)* | 2.0 (1.5, 2.5) | 2.7 (2.1, 3.2) | 2.1 (1.5, 2.8) | 1.7 (0.8, 2.6) |
| Microvascular Flow (Secondary)** | 233 (195, 270) | 359 (320, 398) | 279 (228, 330) | 234 (174, 294) |
| Cerebrovascular Function | ||||
| TOI, % Oxygenation Change (Primary) | 1.68 (1.42, 1.94) | 1.44 (1.25, 1.64) | 1.64 (1.29, 2.00) | 1.64 (1.35, 1.93) |
| O2-Hb (Primary) | 1.04 (0.88, 1.21) | 0.80 (0.66, 0.94) | 1.05 (0.82, 1.27) | 0.91 (0.71, 1.10) |
| Framingham Stroke Risk Profile* | 10.1 (9.6, 10.5) | 8.3 (8.0, 8.7) | 10.4 (9.8, 11.0) | 9.0 (8.5, 9.5) |
| Subjective Cognitive Complaints | ||||
| Attention / Executive Function (Secondary)* | 1.91 (1.77, 2.04) | 1.88 (1.77, 1.99) | 1.84 (1.66, 2.01) | 2.04 (1.89, 2.19) |
| Psychomotor Praxis (Secondary)* | 1.34 (1.91, 1.48) | 1.41 (1.31, 1.50) | 1.48 (1.30, 1.66) | 1.56 (1.43, 1.69) |
| Memory (Secondary) | 2.05 (1.91, 2.19) | 2.02 (1.92, 2.12) | 2.00 (1.82, 2.17) | 2.15 (2.01, 2.28) |
*
P<.05 for adjusted, post-treatment comparisons of C-LIFE and SEPA
**
P < .01 for adjusted, post-treatment comparisons of C-LIFE and SEPA.
TOI = tissue oxygenation index from functional near infrared spectroscopy assessments; O2-Hb = oxygenated hemoglobin from functional near infrared spectroscopy assessments.