Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 30;13:3778. doi: 10.1038/s41467-022-30463-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — A Distribution of PPM1D truncating mutations in solid tumor sequencing data from GENIE (v5.0) obtained from cBioportal (www.cbioportal.org). B Effects of different truncations on the thermal stability of PPM1D by differential scanning calorimetry. N = 3 independent sample runs. Data are presented as mean values ± SD. Source data are provided as a Source Data file. C Circular dichroism analysis of PPM1D_1–420 (black), PPM1D_1–400 (pink) and PPM1D_1–377 (brown). D Relative differences in deuterium uptake between PPM1D_1–420 and PPM1D_1–400 (top) and between PPM1D_1–420 and PPM1D_1–377 (bottom) as assessed by HDX-MS. Vertical tick marks between peptides on the X-axis are shown to indicate regions of missing coverage. The bars below the X-axis represent the N-terminus (purple), loop (brown), hinge (cyan), flap (light purple), and C-terminus (black) of the protein.