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. 2022 Jun 30;13:3780. doi: 10.1038/s41467-022-31587-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a STED images show claudin-15 (cyan) meshworks are depolymerized by claudin-4 (magenta), similar to claudin-2 (see Fig. 5). n = 4 each for intensity and area, representative of 3 independent experiments. Two-tail unpaired t-test. **P = 0.003. b Claudin-7 (cyan) strand intensity is reduced and meshworks are rearranged in response to claudin-4 (magenta) expression. n = 4 each for intensity and area, representative of 3 independent experiments. Two-tail unpaired t-test. ***P < 0.0001. c Claudin-19 (cyan) strand meshworks collapse and form dense bundles upon claudin-4 (magenta) expression. n = 3 each for intensity and area, representative of 3 independent experiments. Two-tail unpaired t-test. *P = 0.019 (area). For each image set, progressive zooms are shown from left to right. Scales: 2 µm, 500 nm, 100 nm. In all plots, each data point represents the mean of 12–16 cells in 1 sample. Data are presented as mean ± SD and included in the Source Data file.