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. 2022 Jun 30;12:11086. doi: 10.1038/s41598-022-14832-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CSP7 inhibits autophagy dysregulation in 1X-BLM-induced PF. (A) Representative Western blot images showing expression of p53, p53^S15P, LC3BII, p62 and ATG12-ATG5 in lung homogenates of 1X-BLM-PF WT mice (n = 6–7 per group) treated with CSP7. β-actin serves as loading control. MW: Molecular weight. kDa: Kilodalton. (B) Bar graph showing decreased expression of LC3B, p62 and ATG5 mRNA in the lungs of CSP7 treated 1X-BLM-PF mice (n = 6). Representative immunohistochemistry images showing reduced expression of (C) LC3B and (D) p62 by CSP7 in the lung tissue sections of CSP7 treated 1X-BLM-PF WT mice. Scale bar: 20 μm. (E) Representative immunoblot images showing p53, p53^S15P, LC3BII, p62 and ATG12-ATG5 expression in AECs isolated from WT mice with 1X-BLM-induced PF and exposed to CSP7. β-actin serves as loading control. MW: Molecular weight. kDa: Kilodalton. Each experiment was repeated at least 2 times and data is presented as mean + SD and p values were obtained by one-way Anova with Turkey’s multiple comparison test and log-rank tests, respectively.