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. 2022 Jun 30;12:11086. doi: 10.1038/s41598-022-14832-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CSP7 mitigates autophagy dysregulation in 8X-BLM-induced PF. (A) Representative western blot images showing the expression of p53, p53^S15P, LC3BII, p62 and ATG12-ATG5 in lung homogenates of CSP7 treated WT mice (n = 5) with 8X-BLM-induced existing PF. β-actin serves as loading control. MW: Molecular weight. kDa: Kilodalton. (B) Bar graph showing increased expression of LC3B, p62 and ATG5 mRNA in the lungs of 8X-BLM-PF WT mice, which is inhibited upon CSP7 treatment. Representative immunohistochemistry images showing inhibition of (C) LC3B and (D) p62 expression by CSP7 in lungs of WT mice with 8X-BLM-PF. Scale bar: 20 μm. (E) Representative immunoblot images showing inhibition of p53, p53^S15P, LC3BII, p62 and ATG12-ATG5 expression in AECs isolated from WT mice with 8X-BLM-induced existing PF treated with CSP7 in vivo. β-actin serves as loading control. MW: Molecular weight. kDa: Kilodalton. Each experiment was repeated at least 2–3 times and data is presented as mean + SD and p values were obtained by one-way Anova with Turkey’s multiple comparison test and log-rank tests, respectively.