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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Glaucoma. 2022 Mar 29;31(7):479–487. doi: 10.1097/IJG.0000000000002027

Table 1:

Racial Discrepancies in Response to Topical Therapies

AD Patients Non-AD Patients
Drug Treated IOP (mm Hg) Untreated/Baseline IOP (mm Hg) Treated IOP (mm Hg) Untreated/Baseline IOP (mm Hg)
Kass et al, 20023 Variety 19.3±2.3 23.9±3.2 19.3±2.1 23.9±2.8
Sommer et al, 199119 Variety 20 (exact not provided) 21.48 ±6.46 18.69±3.23 24.15±5.23
Netland et al, 200120 Travoprost (0.004% and 0.0015%), latanoprost 0.005%, and timolol 0.5% Travoprost 0.004%
8 AM: 18.8
10 AM: 16.7
4 PM: 16.6
Travoprost 0.0015%
8 AM: 19.4
10 AM: 18.8
4 PM: 17.8
Latanoprost
8 AM: 19.7
10 AM: 18.3
4 PM: 18.3
Timolol
8 AM: 22.3
10 AM: 21.0
4 PM: 20.9		 Travoprost 0.004%
8 AM: 26.8
10 AM: 25.0
4 PM: 24.0
Travoprost 0.0015%
8 AM: 26.1
10 AM: 25.0
4 PM: 24.3
Latanoprost
8 AM: 27.6
10 AM: 25.9
4 PM: 25.2
Timolol
8 AM: 27.2
10 AM: 25.4
4 PM: 24.8		 Travoprost 0.004%
8 AM: 20.0
10 AM: 18.6
4 PM: 18.4
Travoprost 0.0015%
8 AM: 19.4
10 AM: 18.2
4 PM: 18.2
Latanoprost
8 AM: 19.3
10 AM: 18.0
4 PM: 18.6
Timolol
8 AM: 20.3
10 AM: 19.6
4 PM: 19.6		 Travoprost 0.004%
8 AM: 26.8
10 AM: 25.2
4 PM: 24.7
Travoprost 0.0015%
8 AM: 26.4
10 AM: 24.7
4 PM: 24.1
Latanoprost
8 AM: 26.6
10 AM: 25.0
4 PM: 24.9
Timolol
8 AM: 26.9
10 AM: 25.4
4 PM: 24.6
Netland et al, 200321
(Pooled data)		 Travoprost 0.004%, latanoprost 0.005%, and timolol 0.5% Travoprost
8 AM: 18.9
10 AM: 16.8
4 PM: 16.7		 Travoprost
8 AM: 27.0
10 AM: 25.2
4 PM: 24.3		 Travoprost
8 AM: 20.2
10 AM: 18.9
4 PM: 18.6		 Travoprost
8 AM: 27.0
10 AM: 25.4
4 PM: 24.9
Kitnarong et al, 200424 Latanoprost 0.005% and timolol 0.5% Timolol
8 AM: 19.2±6.3
10 AM: 17.1±3.7
Latanoprost
8 AM: 16.1±3.7
10 AM: 15.8±3.1		 Timolol
8 AM: 24.8±7.2
10 AM: 24.2±7.6
Latanoprost
8 AM: 23.4±6.8
10 AM: 25.8±6.1		 Timolol
8 AM: 17.1±3.3
10 AM: 16.2±4.5
Latanoprost
8 AM: 17.5±3.5
10 AM: 16.7±2.8		 Timolol
8 AM: 21.7±3.4
10 AM: 21.9±2.6
Latanoprost
8 AM: 22.7±2.2
10 AM: 22.6±3.1
Mansberger et al, 200725 Nonselective β-adrenergic antagonists, prostaglandin analogues β-adrenergic antagonists: 19.6±2.8
Prostaglandins: 17.5±3.8		 β-adrenergic antagonists: 25.8±3.0
Prostaglandins: 25.3±3.9		 β-adrenergic antagonists: 19.6±3.0
Prostaglandins: 18.3±3.5		 β-adrenergic antagonists: 26.0±2.8
Prostaglandins: 24.5±3.4
Birt et al, 201026
(Treated: 24-week data)
(AD patients a portion of Other (18/33))		 Bimatoprost, travoprost, and latanoprost Bimatoprost: 17.0±14.7
Travoprost: 18.6±1.9
Latanoprost: 19.0±2.3		 Bimatoprost: 25.9±2.5
Travoprost: 29.2±4.6
Latanoprost: 27.2±3.4		 Bimatoprost: 18.7±1.9
Travoprost: 18.3±4.6
Latanoprost: 17.0±3.8		 Bimatoprost: 28.3±2.8
Travoprost: 27.8±3.3
Latanoprost: 29.0±3.7

African descent (AD), Intraocular pressure (IOP)