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. 2022 Jun 30;12:11047. doi: 10.1038/s41598-022-14944-x

Table 1.

Effect of WSWPE on hematological and blood clotting parameters in rats.

Parameter 28 days treatment (mg/kg/day) 14 days recovery (mg/kg/day)
G1 (0) G2 (100) G3 (300) G4 (1000) G1R (0) G4R (1000)
Males
RBC (106/µL) 7.60 ± 0.05 7.74 ± 0.12 6.50 ± 1.64 7.67 ± 0.24 8.18 ± 0.41 6.73 ± 1.15#
HGB (g/dL) 13.40 ± 0.00 13.42 ± 0.22 12.60 ± 2.64 13.64 ± 0.48 13.96 ± 0.64 11.90 ± 2.14
HCT (%) 41.38 ± 0.31 42.04 ± 0.28 38.30 ± 6.82 42.08 ± 1.87 43.48 ± 2.35 39.42 ± 2.18#
MCV (fL) 54.46 ± 0.09 54.34 ± 0.62 60.00 ± 5.41* 54.84 ± 0.71 53.14 ± 0.92 59.94 ± 11.08
MCH (pg) 17.64 ± 0.13 17.36 ± 0.53 19.62 ± 1.42 17.78 ± 0.13 17.08 ± 0.54 17.66 ± 0.55
MCHC (g/dL) 32.36 ± 0.26 31.92 ± 0.63 32.78 ± 1.39 32.42 ± 0.39 32.12 ± 0.82 30.20 ± 5.09
PLT (103/µL) 747.00 ± 15.92 762.80 ± 151.91 534.60 ± 112.18* 696.60 ± 35.18 851.40 ± 212.34 833.20 ± 78.71
RET (%) 1.12 ± 0.23 1.08 ± 0.23 1.08 ± 0.30 1.00 ± 0.20 1.08 ± 0.23 1.04 ± 0.26
WBC (103/µL) 13.38 ± 0.16 12.36 ± 0.21 17.52 ± 2.44* 13.00 ± 1.12 18.00 ± 3.57 16.50 ± 4.37
NEU (%) 25.80 ± 2.39 26.40 ± 2.51 26.00 ± 1.87 26.00 ± 1.58 27.20 ± 1.92 26.60 ± 2.07
LYM (%) 72.20 ± 2.28 71.80 ± 1.92 72.40 ± 2.07 72.20 ± 2.28 71.00 ± 1.58 71.60 ± 1.95
MONO (%) 1.20 ± 0.84 0.60 ± 0.55 0.60 ± 0.89 0.80 ± 0.84 0.60 ± 0.55 0.80 ± 0.84
EOS (%) 0.60 ± 0.89 1.00 ± 0.71 1.00 ± 0.71 0.80 ± 0.84 1.20 ± 0.84 0.80 ± 0.84
BASO (%) 0.20 ± 0.45 0.20 ± 0.45 0.00 ± 0.00 0.20 ± 0.45 0.00 ± 0.00 0.20 ± 0.45
PT (sec) 19.29 ± 2.95 16.15 ± 0.89 18.90 ± 1.43 14.50 ± 1.99* 16.26 ± 3.13 16.03 ± 1.85
APTT (sec) 20.90 ± 4.83 20.58 ± 3.25 18.76 ± 2.70 20.48 ± 1.11 19.99 ± 2.41 20.69 ± 1.80
Females
RBC (106/µL) 6.20 ± 0.95 6.70 ± 0.84 6.02 ± 0.02 5.91 ± 0.12 7.31 ± 0.58 7.97 ± 0.38
HGB (g/dL) 11.94 ± 1.15 12.80 ± 1.73 11.68 ± 0.04 11.22 ± 0.22 13.20 ± 1.31 13.98 ± 0.49
HCT (%) 38.02 ± 2.51 37.82 ± 5.50 45.12 ± 0.34* 41.52 ± 0.76 40.22 ± 2.30 42.56 ± 2.47
MCV (fL) 61.94 ± 5.35 56.38 ± 1.18* 75.00 ± 0.38* 70.24 ± 0.15* 55.44 ± 2.14 53.36 ± 0.75
MCH (pg) 19.42 ± 1.69 19.10 ± 0.31 19.42 ± 0.11 18.98 ± 0.25 18.16 ± 0.83 17.54 ± 0.34
MCHC (g/dL) 31.38 ± 1.31 33.90 ± 0.51* 25.90 ± 0.19* 27.04 ± 0.26* 32.76 ± 1.76 32.88 ± 0.86
PLT (103/µL) 798.20 ± 159.93 850.80 ± 67.13 672.60 ± 3.58 550.00 ± 266.23 993.60 ± 203.13 888.80 ± 107.36
RET (%) 1.04 ± 0.17 1.04 ± 0.26 1.08 ± 0.23 1.00 ± 0.14 1.08 ± 0.23 1.04 ± 0.17
WBC (103/µL) 12.04 ± 1.88 13.40 ± 5.39 13.34 ± 0.11 15.20 ± 0.64 14.74 ± 3.95 15.32 ± 2.66
NEU (%) 25.80 ± 2.39 26.40 ± 2.51 26.00 ± 1.87 26.00 ± 1.58 27.20 ± 1.92 26.60 ± 2.07
LYM (%) 72.20 ± 2.28 71.80 ± 1.92 72.40 ± 2.07 72.20 ± 2.28 71.00 ± 1.58 71.60 ± 1.95
MONO (%) 1.20 ± 0.84 0.60 ± 0.55 0.60 ± 0.89 0.80 ± 0.84 0.60 ± 0.55 0.80 ± 0.84
EOS (%) 0.60 ± 0.89 1.00 ± 0.71 1.00 ± 0.71 0.80 ± 0.84 1.20 ± 0.84 0.80 ± 0.84
BASO (%) 0.20 ± 0.45 0.20 ± 0.45 0.00 ± 0.00 0.20 ± 0.45 0.00 ± 0.00 0.20 ± 0.45
PT (sec) 17.79 ± 3.21 18.95 ± 1.05 18.02 ± 0.48 14.07 ± 1.48* 16.75 ± 1.37 18.36 ± 2.31
APTT (sec) 16.91 ± 2.71 18.29 ± 0.34 18.50 ± 1.60 18.53 ± 1.29 18.61 ± 1.95 21.18 ± 1.16#

Data is presented as Mean ± Standard Deviation (n = 5 animals per group per sex). *p < 0.05 vs. G1 (One-Way ANOVA followed by Dunnett’s post-hoc multiple comparison test), #p < 0.05 vs. G1R (Student’s t test).

RBC, red blood cell count; HGB, Hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PLT, platelet; RET, reticulocyte; WBC, white blood cell count; NEU, neutrophils, LYM, lymphocytes; MONO, monocytes; EOS, eosinophils; BASO, basophils; PT, prothrombin time; APTT, activated partial thromboplastin time.