Table 3.
Parameter | 28 days treatment (mg/kg/day) | 14 days recovery (mg/kg/day) | ||||
---|---|---|---|---|---|---|
G1 (0) | G2 (100) | G3 (300) | G4 (1000) | G1R (0) | G4R (1000) | |
Males | ||||||
Specific gravity | 1.025 ± 0.011 | 1.030 ± 0.000 | 1.030 ± 0.000 | 1.024 ± 0.013 | 1.003 ± 0.003 | 1.003 ± 0.003 |
pH | 6.20 ± 0.67 | 5.60 ± 0.82 | 5.60 ± 0.82 | 5.60 ± 0.82 | 6.70 ± 0.27 | 6.70 ± 0.27 |
Colour: yellow | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
Turbidity: clear | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
Bilirubin | ||||||
(a) Negative | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
(b) Positive | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Protein | ||||||
(a) Negative | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
(b) Positive | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Glucose | ||||||
(a) Negative | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
(b) Positive | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Females | ||||||
Specific gravity | 1.024 ± 0.013 | 1.024 ± 0.013 | 1.030 ± 0.000 | 1.030 ± 0.000 | 1.000 ± 0.000 | 1.000 ± 0.000 |
pH | 6.00 ± 0.61 | 6.10 ± 0.65 | 6.50 ± 0.00 | 6.20 ± 0.67 | 6.60 ± 0.22 | 6.50 ± 0.00 |
Colour: yellow | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
Turbidity: clear | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
Bilirubin | ||||||
(a) Negative | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
(b) Positive | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Protein | ||||||
(a) Negative | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
(b) Positive | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Glucose | ||||||
(a) Negative | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 |
(b) Positive | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Data is presented as Mean ± Standard Deviation for specific gravity and pH and number of animals for yellow colour, no turbidity and for presence or absence of bilirubin, protein and glucose in the urine.