Table 4.
Effect of WSWPE on relative organ weights expressed as a percentage of the fasting body weights.
| Parameter | 28 days treatment (mg/kg/day) | 14 days recovery (mg/kg/day) | ||||
|---|---|---|---|---|---|---|
| G1 (0) | G2 (100) | G3 (300) | G4 (1000) | G1R (0) | G4R (1000) | |
| Males | ||||||
| Body weight (g) | 243.00 ± 19.36 | 241.90 ± 18.97 | 243.20 ± 15.69 | 242.60 ± 18.35 | 274.40 ± 18.28 | 274.10 ± 13.18 |
| Liver | 3.641 ± 0.327 | 3.521 ± 0.107 | 3.467 ± 0.064 | 3.649 ± 0.256 | 3.272 ± 0.274 | 3.345 ± 0.624 |
| Spleen | 0.349 ± 0.029 | 0.334 ± 0.024 | 0.338 ± 0.026 | 0.334 ± 0.032 | 0.283 ± 0.069 | 0.290 ± 0.078 |
| Heart | 0.332 ± 0.019 | 0.331 ± 0.010 | 0.334 ± 0.007 | 0.335 ± 0.004 | 0.295 ± 0.016 | 0.308 ± 0.056 |
| Thymus | 0.082 ± 0.006 | 0.083 ± 0.005 | 0.083 ± 0.002 | 0.085 ± 0.004 | 0.062 ± 0.010 | 0.066 ± 0.024 |
| Kidneys | 0.860 ± 0.052 | 0.858 ± 0.068 | 0.855 ± 0.032 | 0.858 ± 0.058 | 0.770 ± 0.083 | 0.848 ± 0.183 |
| Adrenals | 0.015 ± 0.001 | 0.014 ± 0.001 | 0.016 ± 0.001 | 0.015 ± 0.001 | 0.011 ± 0.002 | 0.012 ± 0.003 |
| Testes | 1.165 ± 0.164 | 1.108 ± 0.109 | 1.114 ± 0.074 | 1.160 ± 0.071 | 1.044 ± 0.092 | 1.010 ± 0.084 |
| Brain | 0.777 ± 0.045 | 0.777 ± 0.052 | 0.760 ± 0.020 | 0.777 ± 0.058 | 0.649 ± 0.047 | 0.654 ± 0.090 |
| Females | ||||||
| Body weight (g) | 202.40 ± 8.96 | 202.20 ± 8.70 | 202.00 ± 9.90 | 201.40 ± 7.44 | 216.60 ± 13.74 | 216.80 ± 11.42 |
| Liver | 3.258 ± 0.151 | 3.328 ± 0.376 | 3.294 ± 0.138 | 3.338 ± 0.398 | 2.819 ± 0.129 | 2.771 ± 0.272 |
| Spleen | 0.439 ± 0.066 | 0.408 ± 0.014 | 0.424 ± 0.017 | 0.426 ± 0.013 | 0.196 ± 0.038 | 0.227 ± 0.068 |
| Heart | 0.319 ± 0.019 | 0.336 ± 0.022 | 0.313 ± 0.011 | 0.339 ± 0.036 | 0.293 ± 0.011 | 0.298 ± 0.035 |
| Thymus | 0.102 ± 0.006 | 0.106 ± 0.008 | 0.108 ± 0.009 | 0.101 ± 0.007 | 0.073 ± 0.014 | 0.082 ± 0.020 |
| Kidneys | 0.874 ± 0.030 | 0.870 ± 0.017 | 0.874 ± 0.040 | 0.879 ± 0.015 | 0.659 ± 0.013 | 0.666 ± 0.021 |
| Adrenals | 0.029 ± 0.002 | 0.029 ± 0.002 | 0.029 ± 0.002 | 0.029 ± 0.001 | 0.023 ± 0.001 | 0.021 ± 0.006 |
| Testes | 0.044 ± 0.003 | 0.044 ± 0.003 | 0.043 ± 0.001 | 0.043 ± 0.003 | 0.028 ± 0.003 | 0.030 ± 0.004 |
| Brain | 0.878 ± 0.023 | 0.866 ± 0.042 | 0.864 ± 0.021 | 0.893 ± 0.031 | 0.783 ± 0.014 | 0.804 ± 0.065 |
Data is presented as Mean ± Standard Deviation. Body weight of animals presented in the table represents their fasting body weights on the day of necropsy.