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. 2022 Jun 30;12:10845. doi: 10.1038/s41598-022-13875-x

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term clinical efficacy of bimodal neuromodulation. (a,b) Scatter plots of THI or TFI scores are shown that include each treatment-compliant individual at baseline versus end of treatment (12-week final visit) for all arms pooled together to represent bimodal neuromodulation in general. (c,d) Scatter plots of THI or TFI scores are shown that include each treatment-compliant individual at baseline versus 12-month post-treatment visit for all arms pooled together. All individuals who completed at least the assessments displayed in each figure were included to maximize the total number of subjects plotted in each figure, leading to a large sample size for each plot. Compliance to treatment is defined as ≥ 36 h treatment at final. Data points are jittered for visibility.