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. 2022 Mar 7;39(7):1363–1392. doi: 10.1007/s11095-022-03193-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Distribution of SR-101 in the cervical spinal cord 20 min after intracisterna magna (i.c.m.) injection in rats. SR-101 was administered without inhibitor (A, B). The fluorescence signals of SR-101 were predominantly detected in the leptomeninges at the surface of the spinal cord. The fluorescence intensity of SR-101 was diminished in the leptomeninges and instead increased in the parenchyma of the spinal cord pre-administered with taurocholate (C, D) and digoxin (E, F). Scale bars: 300 μm. Subfigures B,D,F are enlarged spinal cord images of A,C,E, respectively. The figure was reprinted (adapted) with permission from reference (35). Copyright 2022 American Chemical Society.