Table IV.
Comparison of Total Transporter Protein Expression Between Cerebral Leptomeninges and Choroid Plexus in Pig
| Transporter | Protein expression per head (pmol/pig cerebrum) | Ratio | |
|---|---|---|---|
| cerebral leptomeninges | choroid plexus | leptomeninges /choroid plexus | |
| Drug efflux transporter | |||
| MDR1/ABCB1 | 25.1 ± 0.9 | 13.6 ± 0.1 | 1.84 |
| BCRP/ABCG2 | 36.1 ± 0.9 | 8.42 ± 0.20 | 4.29 |
| Organic anion transporter | |||
| OAT1/SLC22A6 | 125 ± 3 | 14.0 ± 0.2 | 8.94 |
| OAT3/SLC22A8 | 54.8 ± 1.8 | 7.06 ± 0.35 | 7.76 |
| MRP1/ABCC1 | ULQ(<5.62) | 8.04 ± 0.18 | <0.699 |
| MRP3/ABCC3 | 3.80 ± 0.12 | 4.56 ± 0.11 | 0.833 |
| MRP4/ABCC4 | 4.07 ± 0.21 | 2.65 ± 0.08 | 1.54 |
| OATP1A2/SLCO1A2 | ULQ (<8.43) | 40.1 ± 0.6 | <0.21 |
| OATP2B1/SLCO2B1 | 4.72 ± 0.16 | 2.99 ± 0.07 | 1.58 |
| OATP3A1/SLCO3A1 | ULQ (<1.63) | 10.9 ± 0.1 | <0.149 |
| Organic cation transporter | |||
| MATE1/SLC47A1 | 15.2 ± 0.9 | 0.464 ± 0.042 | 32.8 |
| OCT2/SLC22A2 | 40.6 ± 1.2 | 0.452 ± 0.021 | 89.8 |
| OCTN2/SLC22A5 | ULQ (<2.65) | 12.6 ± 0.2 | <0.211 |
| Energy source transporter | |||
| GLUT1/SLC2A1 | 134 ± 8 | 112 ± 1 | 1.20 |
| MCT1/SLC16A1 | 15.8 ± 0.9 | 13.1 ± 0.3 | 1.21 |
| Thyroid hormone transporter | |||
| MCT8/SLC16A2 | 10.0 ± 0.6 | 8.01 ± 0.10 | 1.25 |
| Amino acid transporter | |||
| xCT/SLC7A11 | 72.8 ± 3.3 | 11.2 ± 0.3 | 6.50 |
| ATA2/SLC38A2 | 9.40 ± 0.69 | ULQ (<5.49) | >1.71 |
| Peptide transporter | |||
| PEPT2/SLC15A2 | 16.4 ± 0.5 | 2.83 ± 0.09 | 5.79 |