Table 1:
Patient and wound characteristics are the first study visit. Means or percentages with 95% CI and logistic regression based on healed by week 16 outcome.
| Means or Percentages (%) | Odds ratio | |||||
|---|---|---|---|---|---|---|
| Covariate | N | Full cohort | Unhealed | Healed | OR 96% CI | p-value |
| 33 | NY 16.18(11.40,22.00) | 17.42(11.38,24.99) | 13.89(6.87,24.06) | 1.07(0.45,2.54) | 0.875 | |
| Sex (male)% | 204 | 73.04 (66.90,79.18) | 74.24 (66.68,81.80) | 70.83 (60.08,81.59) | 1.26 (0.67,2.40) | 0.473 |
| Ethnicity (not Hispanic)% | 204 | 88.67 (84.27,93.07) | 85.50 (79.39,91.61) | 94.44 (89.02,99.86) | 2.48 (0.88,6.96) | 0.085 |
| Age at enrollment | 202 | 57.80 (56.46,59.14) | 57.51 (55.85,59.17) | 58.32 (55.99,60.65) | 1.01 (0.98,1.04) | 0.698 |
| Black% | 204 | 58.33 (51.51,65.16) | 57.58 (49.03,66.12) | 59.72 (48.12,71.33) | 1.08 (0.60,1.93) | 0.807 |
| White% | 204 | 36.76 (30.09,43.44) | 35.61 (27.33,43.88) | 38.89 (27.35,50.42) | 1.13 (0.62,2.04) | 0.689 |
| Body mass index | 193 | 33.10 (31.42,34.77) | 31.91 (30.62,33.21) | 35.27 (31.14,39.40) | 1.02 (0.99,1.06) | 0.160 |
| Age of diabetes onset | 180 | 39.44 (37.54,41.34) | 39.55 (37.06,42.03) | 39.28 (36.28,42.28) | 1.00 (0.98,1.02) | 0.958 |
| Duration of Diabetes | 178 | 18.32 (16.73,19.91) | 17.56 (15.48,19.63) | 19.49 (17.00,21.98) | 1.02 (0.99,1.05) | 0.272 |
| ho Congestive Heart Disease % | 200 | 23.50 (17.57,29.43) | 21.71 (14.50,28.92) | 26.76 (16.21,37.31) | 1.30 (0.66,2.55) | 0.447 |
| ho Peripheral Arterial Disease % | 198 | 22.22 (16.38,28.06) | 24.03 (16.56,31.50) | 18.84 (9.38,28.30) | 0.64 (0.31,1.33) | 0.231 |
| ho Adequate Arterial Flow % | 197 | 95.94 (93.16,98.72) | 94.53 (90.54,98.52) | 98.55 (95.66,101.44) | 3.93(0.47,32.65) | 0.205 |
| ho Chronic Kidney Disease % | 166 | 29.52 (22.51,36.53) | 30.09 (21.50,38.68) | 28.30 (15.77,40.84) | 0.76 (0.37,1.57) | 0.462 |
| ho Dialysis % | 200 | 11.52 (6.59,16.44) | 15.04 (8.35,21.74) | 3.85 (−1.56,9.25) | 0.19 (0.04,0.87) | 0.034 |
| HemoA1c | 157 | 7.97 (7.57,8.37) | 7.92 (7.38,8.47) | 8.04 (7.48,8.61) | 1.05 (0.92,1.20) | 0.450 |
| Glucose | 182 | 158.01 (149.10,166.92) | 162.36 (150.02,174.69) | 150.55 (138.62,162.49) | 1.00 (0.99,1.00) | 0.105 |
| eGFR | 133 | 47.89 (42.61,53.18) | 44.42 (38.38,50.46) | 55.43 (44.97,65.88) | 1.01 (1.00,1.02) | 0.152 |
| Serum Creatine | 165 | 3.68 (1.49,5.86) | 4.04 (0.98,7.11) | 2.91 (0.71,5.10) | 0.99 (0.96,1.02) | 0.598 |
| # of Wounds | 202 | 1.35 (1.25,1.44) | 1.39 (1.27,1.52) | 1.26 (1.11,1.42) | 0.79 (0.51,1.22) | 0.282 |
| Wound Duration | 196 | 34.85 (28.00,41.70) | 40.10 (30.59,49.60) | 25.41 (16.88,33.95) | 0.99 (0.98,1.00) | 0.050 |
| ln Wound Duration | 193 | 2.91 (2.74,3.07) | 3.08 (2.89,3.27) | 2.59 (2.29,2.89) | 0.71 (0.54,0.93) | 0.012 |
| Wound area | 200 | 14.50 (8.44,20.55) | 18.60 (10.09,27.11) | 6.87 (−0.12,13.86) | 0.99 (0.97,1.00) | 0.111 |
| ln Wound Area | 200 | 0.92 (0.65,1.19) | 1.39 (1.07,1.71) | 0.05 (−0.40,0.50) | 0.70 (0.59,0.83) | <0.0001 |
| Wagner grade | 192 | 3.28 (3.12,3.44) | 3.28 (3.07,3.48) | 3.27 (3.01,3.53) | 1.00 (0.76,1.30) | 0.976 |
| Abnormal Semes Weinstein testing | 194 | 71.13 (64.70,77.57) | 70.77 (62.85,78.69) | 71.88 (60.56,83.19) | 1.25 (0.64,2.47) | 0.514 |
| ho Neuropathy % | 196 | 88.78 (84.32,93.23) | 86.51 (80.46,92.56) | 92.86 (86.67,99.04) | 2.31 (0.81,6.60) | 0.118 |
| ho Amputation % | 202 | 48.01 (40.95,55.14) | 47.69 (38.86,56.63) | 48.61 (37.65,60.69) | 1.24 (0.70,2.21) | 0.466 |
| Wound Depth Dermis only % | 204 | 27.45 (21.28,33.63) | 30.30 (22.36,38.25) | 22.22 (12.38,32.06) | 0.60 (0.31,1.19) | 0.144 |