Table 2.

Results of the whole‐brain voxel‐based morphometry analyses^*

	Brain region	x, y, z†	T	Cluster size, voxels‡
Structural results at P FWE‐corr < 0.05, estimated with TFCE
GMV differences between adolescents with juvenile FM and controls
Contrast: juvenile FM < controls	aMCC R	9, 22, 30	1018.43§	113
Correlations between GMV and clinical symptoms in adolescents with juvenile FM
Functional disability (FDI)
↑GMV	IFG pars triangularis L	−54, 22, 4	1784.78§	340
Structural results at P uncorr < 0.001, Ke >50 voxels
GMV differences between adolescents with juvenile FM and controls
Contrast: juvenile FM < controls	aMCC R	9, 22, 30	4.14	983
Correlations between GMV and clinical symptoms in adolescents with juvenile FM
Functional disability (FDI)
↑GMV	IFG pars triangularis L	−54, 22, 4	6.47	805
↑GMV	IFG pars opercularis R	57, 14, 15	4.35	242
↑GMV	MFG L	−42, 12, 48	4.13	191
↑GMV	IFG pars orbitalis R	42, 21, −14	3.81	117
Fatigue (PROMIS)
↑GMV	Inferior temporal cortex L	−60, −16, −33	5.03	115
↑GMV	IFG pars triangularis L	−54, 26, −3	4.83	317
↑GMV	IFG pars orbitalis R	32, 27, −21	4.63	366
↑GMV	IFG pars triangularis L	−50, 28, 9	4.54	82
↑GMV	IFG pars orbitalis L	−30, 21, −20	4.18	76
Pain interference (BPI)
↑GMV	IFG pars triangularis L	−38, 26, 10	4.97	157
↑GMV	IFG pars opercularis R	52, 16, 12	4.21	264
↑GMV	Superior frontal cortex R	28, −3, 66	4.11	154

^* P _FWE‐corr = family wise error rate–corrected P value; GMV = gray matter volume; FM = fibromyalgia; aMCC = anterior midcingulate cortex; R = right; FDI = Functional Disability Inventory; IFG = inferior frontal gyrus; L = left; P _uncorr = uncorrected P value; MFG = middle frontal gyrus; PROMIS = Patient‐Reported Outcomes Measurement Information System; BPI = Brief Pain Inventory.

^†Anatomic coordinates (x, y, z) are given in Montreal Neurological Institute space.

^‡Voxel size 1.5 × 1.5 × 1.5 mm.

^§Threshold‐free cluster enhancement (TFCE) values.