Extended Data Figure 9. Caspase-7 and perforin phenocopy defense against C. violaceum infection.
a-b, Mice were infected IP with 104 C. violaceum and bacterial burdens in the liver were determined 3 days post infection for separately bred mice (a) or littermate-controlled mice (b). c, Ly5A+ splenocytes were harvested from wildtype mice and expanded ex vivo in IL-2 for the NK adoptive transfer experiments in Fig. 4e–f. Shown is the percentage of transferred cells that were NK cells. d, NK cell adoptive transfer schematic for experiments in Fig. 4d–e. Data are pooled from 2 experiments in (a), representative of two experiments in (b), and representative of 3 experiments in (c). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (One way ANOVA (a) or two-sided Mann-Whitney U test (b)). Bars indicate mean with standard deviation (c). Exact p and n values in Source Data EDF9.