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. 2022 Jun 30;8:301. doi: 10.1038/s41420-022-01088-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–c In situ RNA hybridization of Drd1, Tac1, Pdyn, Drd2, Adora2a and Penk showing that the number of D1-MSNs was decreased by ~70% and that the number of D2-MSNs was increased by ~26% in the striatum of the Dlx5/6-CIE; Rosa-Sp9-OE/ + mice compared to control mice at P10 (Student’s t-test, **p < 0.01, ***p < 0.001, n = 3, mean ± SEM). d–f In situ RNA hybridization showing that the number of D1-MSNs was decreased by ~70% and that the number of D2-MSNs was increased by ~25% in the striatum of the Sp9-Cre; Rosa-Sp9-OE/ + mice compared with control mice at P20 (Student’s t-test, **p < 0.01, ***p < 0.001, n = 3, mean ± SEM). g The heatmap showing the expression level of MSN-enriched genes in the Sp9-Cre; Rosa-Sp9-OE/ + and Sp9-Cre striatum at P20 (obtained by bulk RNA sequencing). The expression of the D1-MSN markers was greatly downregulated, and the expression of the D2-MSN markers was significantly upregulated. Scale bar: 500 µm in f for a, b and e, f.