Table 4.

Genetic changes identified in phage-resistant mutants of A. baumannii TP1 generated in vitro.

Phage mutant	Mutation type	Base position in TP1	Quality score	Gene function	Locus in TP1	Mutation
AB-Navy97 mutant 1	SNP	25961	225	Intergenic		T/C
	SNP	3779783	212	Glucose-6-phosphate isomerase	HWQ22_04190	W102I
	Deletion	3786204	217	Glycosyltransferase	HWQ22_04225	ΔL243-N244
	SNP	3813620	225	Sulfonate ABC transporter substrate-binding protein	HWQ22_04355	A123A (silent)
AB-Navy97 mutant 2	Deletion	3786204	217	Glycosyltransferase	HWQ22_04225	ΔL243-N244
AB-Navy97 mutant 3	Deletion	3786204	217	Glycosyltransferase	HWQ22_04225	ΔL243-N244
AB-Navy1 mutant 1	SNP	995279	175	Ornithine uptake porin CarO type 3	HWQ22_09280	W183am
AB-Navy1 mutant 2	Deletion	3786204	214	Glycosyltransferase	HWQ22_04225	ΔL243-N244
Maestro mutant 1	Deletion	3786204	214	Glycosyltransferase	HWQ22_04225	ΔL243-N244
Maestro mutant 2	Deletion	3786204	214	Glycosyltransferase	HWQ22_04225	ΔL243-N244
Maestro mutant 3	Insertion	1380798	115	Intergenic		9 bp insertion
	SNP	2895519	222	Intergenic		C/T
	Deletion	3786204	214	Glycosyltransferase	HWQ22_04225	ΔL243-N244
AC4 mutant 1	Deletion	3786204	198	Glycosyltransferase	HWQ22_04225	ΔL243-N244
AC4 mutant 2	Deletion	3786204	214	Glycosyltransferase	HWQ22_04225	ΔL243-N244
AC4 mutant 3	Deletion	3786204	209	Glycosyltransferase	HWQ22_04225	ΔL243-N244
AbTP3phi1 mutant 1	SNP	1696827	222	Intergenic		A/T
	SNP	3779456	222	Glucose-6-phosphate isomerase	HWQ22_04190	S211L
AbTP3phi1 mutant 2	SNP	3778893	222	Glucose-6-phosphate isomerase	HWQ22_04190	Q399oc
AbTP3phi1 mutant 3	Insertion	3794503	167	Polysaccharide biosynthesis tyrosine autokinase	HWQ22_04255	G715 frameshift

All changes are relative to the sequence of strain TP1.