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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Neuroendocrinol. 2021 Sep 10;34(2):e13028. doi: 10.1111/jne.13028

Fig.5. Neurosteroid drug development.

Fig.5.

(A) Structure-activity relationship for identification and optimization of novel neurosteroid analogs as modulators of synaptic and extrasynaptic GABA-A receptors. (B) Novel neurosteroid analogs with potential clinical use in neurological disorders. Ganaxolone and SGE-516 are clinical trials for epilepsy and brain conditions. Alfaxolone is available for veterinary clinical use as anesthetic agent.