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. 2022 Jul 1;11:22. doi: 10.1186/s13619-022-00122-x

Fig. 2.

Fig. 2

Dysregulation of hair regeneration in AGA. A Clinical presentation of a patient with AGA. B Androgen receptors (AR) in the hair follicle dermal papilla sense androgen and promote Dkk1 and TGF-β expression, which retard hair growth. TGF-β further shrinks the blood vessel. AR signaling also antagonizes Wnt/β-catenin signaling in the HF. C GWAS results showing the potential genes involved in AGA and their chromosomal locations. D List of current treatment options for AGA and the possible mechanisms