Table 1.

Neutralizing and binding activities of therapeutic antibodies against WT and Omicron variants.

	Neut in Hela-hACE2 cells							Neut in Huh 7 cells							Fold Change of Spike binding
	IC50 (µg/ml)				Fold Change			IC50 (µg/ml)				Fold Change
	WT	BA.1	BA.1.1	BA. 2	BA .1	BA. 1. 1	BA. 2	WT	BA.1	BA.1.1	BA. 2	BA .1	BA. 1. 1	BA. 2	BA .1	BA. 1. 1	BA. 2
BRII-196	0.020	1.210	0.665	2.087	-61.5	-33.8	-106.1	0.018	0.949	0.877	0.463	-52.5	-48.5	-25.6	-2.0	-2.1	-4.3
BRII-198	0.162	0.184	>100	11.690	-1.1	<-617.6	-72.2	0.107	0.251	>100	3.303	-2.4	<-938.6	-31.0	+4.2	-198.9	-19.8
BRII-Combo	0.031	0.211	1.467	1.177	-6.8	-47.4	-38.1	0.022	0.332	1.168	0.801	-15.5	-54.3	-37.3	+1.9	-2.2	-3.9
S309	0.235	0.376	0.629	6.438	-1.6	-2.7	-27.4	0.056	0.069	0.137	0.387	-1.2	-2.4	-6.9	-1.3	-1.2	-3.4
REGN 10933	0.005	3.058	13.939	28.239	-625.9	-2852.7	-5779.1	0.003	5.463	2.055	11.507	-1959.2	-737.1	-4126.6	-5.8	-4.4	-7.3
REGN 10987	0.006	85.540	>100	0.465	-14398.4	<-16832.3	-78.3	0.007	>100	>100	0.163	<-13402.2	<-13402.2	-21.9	-70.7	-34.7	-1.4
REGN Combo	0.003	3.131	13.890	0.794	-962.9	-4271.2	-244.2	0.005	11.958	3.523	0.264	-2468.0	-727.1	-54.4	-7.0	-6.8	-1.3
COV2-2196	0.001	2.048	19.246	17.467	-1517.5	-1426.6	-12942.9	0.007	9.977	10.494	9.089	1387.9	-1459.8	-1264.3	+1.5	+1.6	-1.3
COV2-2130	0.002	0.512	>100	0.015	-233.0	<-45499.2	-6.9	0.006	0.818	43.402	0.008	-140.9	-7478.3	-1.4	-1.3	-6.0	-1.0
AZ como	0.004	0.370	3.493	0.026	-96.7	-912.5	-6.7	0.005	0.600	1.755	0.009	-113.4	-331.6	-1.7	+1.2	+1.1	+1.0
CB6	0.037	>100	>100	>100	<-2734.9	<-2734.9	<-2734.9	0.060	>100	>100	>100	<-1662.2	<-1662.2	<-1662.2	<-200	<-200	<-200