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. 2022 Jun 17;13:935534. doi: 10.3389/fimmu.2022.935534

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Copyright © 2022 Xu, Zhang, Ma, Chen, Xie, Yu, Wang, Xu and Pan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of candidate genes and the correlation with FOXO3a. (A) Relative expression of FOXO3a between AS (n = 50) and HC (n = 50). (B) Predicting FOXO3a downstream target genes in different transcription factor datasets. Nucleoredoxin (NRX) was excluded because there is no evidence that it may be associated with AS and other autoimmune diseases. (C–H) Relative expression of TGF-β (C), VDR (D), HO-1 (E), HIF-1α (F), Keap1 (G), and Nrf2 (H) between AS and HC. (I–N) Correlation analysis between FOXO3a and TGF-β (I), VDR (J), HO-1 (K), HIF-1α (L), Keap1 (M), and Nrf2 (N) in AS. All data were expressed as mean ± SEM. The differences between AS and HC were analyzed using Mann-Whitney U test. The correlation was analyzed using spearman rank correlation. ^** P < 0.01, ^*** P < 0.001; NS, not significant versus HC group. AS, ankylosing spondylitis; HC, healthy control; r_s , Spearman’s rank correlation coefficient.