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. 2022 Jun 17;13:935534. doi: 10.3389/fimmu.2022.935534

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Copyright © 2022 Xu, Zhang, Ma, Chen, Xie, Yu, Wang, Xu and Pan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FOXO3a regulates TGF-β and HO-1 in Jurkat cells. (A, B) The mRNA levels of TGF-β and HO-1 were obviously increased by Lv-FOXO3a, but markedly decreased by Si-FOXO3a. (C) Representative immunoblots of TGF-β and HO-1 protein. (D, E) Quantification for TGF-β and HO-1. All data were expressed as mean ± SEM of three independent experiments (n = 3). The differences between experimental group and NC group were analyzed using Student’s t-test. ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001 versus NC group. Lv-NC, lentivirus negative control, Lv-FOXO3a, FOXO3a overexpression; Si-NC, siRNA negative control; Si-FOXO3a, FOXO3a knockdown.