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. 2022 Jun 17;12:889711. doi: 10.3389/fcimb.2022.889711

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Copyright © 2022 Chahal, Quintana-Hayashi, Gaytán, Benktander, Padra, King and Linden

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of S. oralis binding to salivary mucins using glycoconjugates. S. oralis IE12 WT was pre-treated with 50 ug/mL of Leb-HSA, SLex-APD-HSA, Lex-APD-HSA or LNT-APD-HSA prior to addition to microtiter plates coated with MUC5B and MUC7/SAG from sample 1. Data shown with background control subtracted. The bars represent mean ± SEM (n=6), ** indicates p ≤ 0.01 and *** p ≤ 0.001, One-way ANOVA, Dunnett´s post hoc test. The results have been reproduced in three independent experiments and a representative experiment is shown here. The structures used for inhibition are depicted using Symbol Nomenclature for Glycans: () = Fuc, () = Gal, () = GlcNAc, () = GalNAc and () = NeuAc.

Inline graphic — Inhibition of S. oralis binding to salivary mucins using glycoconjugates. S. oralis IE12 WT was pre-treated with 50 ug/mL of Leb-HSA, SLex-APD-HSA, Lex-APD-HSA or LNT-APD-HSA prior to addition to microtiter plates coated with MUC5B and MUC7/SAG from sample 1. Data shown with background control subtracted. The bars represent mean ± SEM (n=6), ** indicates p ≤ 0.01 and *** p ≤ 0.001, One-way ANOVA, Dunnett´s post hoc test. The results have been reproduced in three independent experiments and a representative experiment is shown here. The structures used for inhibition are depicted using Symbol Nomenclature for Glycans: () = Fuc, () = Gal, () = GlcNAc, () = GalNAc and () = NeuAc.