Table 1.
Summary of the mouse models used to study the function of IGF1R in development and tumorigenesis.
| Models of IGF1R Function in the Mammary Gland | |||||
|---|---|---|---|---|---|
| Genotype | Biological Context | IGF1R Status | Phenotype | Effect on Tumor Phenotype | Reference |
| Igf1r-/- systemic KO | Development | Deleted | Embryonic lethal, 45% normal birthweight, delayed bone/skin development | N/A | (1) |
| Igf1r+/+ , Igf1r+/- , Igf1r-/- transplantation | Development | Deleted | Limited branch outgrowth and TEB formation during puberty | N/A | (3) |
| WAP-dnIGF1R | Pregnancy | Inhibited; mutated receptor | Decreased branching outgrowth, delayed alveolar density/differentiation during pregnancy | N/A | (8) |
| MMTV-dnIGF1R | Development | Inhibited; mutated receptor | Decreased post-pubertal branching, increased luminal progenitor and basal populations | N/A | (9) |
| MMTV-CD8α-IGF1R | Tumorigenesis | Constitutively activated | Induced tumorigenesis, increased luminal progenitor population | Promoting | (10) |
| MTB-IGF1R | Tumorigenesis | Overexpressed | Induced tumorigenesis | Promoting | (11) |
| Eef1a1-Kras* /WAP-Cre/Igf1rfl/fl | Tumorigenesis | Deleted | Increased tumor latency | Promoting | (12) |
| MMTV-Wnt1/dnIGF1R | Tumorigenesis | Inhibited; mutated receptor | Increased luminal progenitor and basal populations, decreased latency, increased metastasis | Suppressing | (9) |
| MMTV-Wnt1/K8-CreERT /Igf1rfl/fl | Tumorigenesis | Deleted | Increased luminal progenitor and basal populations, decreased latency, increased metastasis | Suppressing | (13) |
N/A, Not Applicable.