Table 3.

Differential gene expression in cAMP/cGMP synthesis and hydrolysis.

Gene	Description	LFCa	padjb
ADCY1	Adenylate cyclase 1	−0.83	1.4E-04***
ADCY2	Adenylate cyclase 2	0.83	n.s.c
ADCY3	Adenylate cyclase 3	−0.82	0.003**
ADCY4	Adenylate cyclase 4	0.27	n.s.
ADCY5	Adenylate cyclase 5	−0.59	0.01*
ADCY6	Adenylate cyclase 6	−0.07	n.s.
ADCY7	Adenylate cyclase 7	0.49	n.s.
ADCY8	Adenylate cyclase 8	−0.52	n/ad
ADCY9	Adenylate cyclase 9	−0.49	2.7E-06*****
ADCY10	Adenylate cyclase 10	0.37	n.s.
GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1	−0.09	n.s.
GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2	−0.20	n.s.
GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1	−0.20	n.s.
GUCY1B2	Guanylate cyclase 1 soluble subunit beta 2	1.47	n.s.
GUCY2A	Guanylate cyclase A, Natriuretic peptide receptor 1, NPR-A	0.18	n.s.
GUCY2B	Guanylate cyclase B, Natriuretic peptide receptor 2, NPR-B	0.08	n.s.
NPR3	Natriuretic peptide receptor 3, NPR-C	0.51	n.s.
GUCY2C	Guanylate cyclase 2C, Guanylate cyclase C	−0.40	n.s.
GUCY2D	Guanylate cyclase 2D, Retinal	0.52	n/a
GUCY2EP	Guanylate cyclase 2E, Pseudogene	1.00	n/a
GUCY2F	Guanylate cyclase 2F, Retinal	−1.26	n/a
GUCY2GP	Guanylate cyclase 2G, Pseudogene	−0.09	n/a
PDE1A	Phosphodiesterase 1A	−0.87	n.s.
PDE1B	Phosphodiesterase 1B	−0.13	n.s.
PDE1C	Phosphodiesterase 1C	−0.55	0.006**
PDE2A	Phosphodiesterase 2A	0.34	n.s.
PDE3A	Phosphodiesterase 3A	−0.29	n.s.
PDE3B	Phosphodiesterase 3B	0.78	0.003**
PDE4A	Phosphodiesterase 4A	−1.18	3.0E-12*****
PDE4B	Phosphodiesterase 4B	−0.37	n.s.
PDE4C	Phosphodiesterase 4C	0.31	n.s.
PDE4D	Phosphodiesterase 4D	−0.68	0.02*
PDE5A	Phosphodiesterase 5A	0.07	n.s.
PDE6A	Phosphodiesterase 6A	1.01	0.05
PDE6B	Phosphodiesterase 6B	−0.02	n.s.
PDE6C	Phosphodiesterase 6C	0.32	n/a
PDE6D	Phosphodiesterase 6D	0.02	n.s.
PDE7A	Phosphodiesterase 7A	0.72	8.6E-04***
PDE7B	Phosphodiesterase 7B	−0.29	n.s.
PDE8A	Phosphodiesterase 8A	0.12	n.s.
PDE8B	Phosphodiesterase 8B	0.66	n.s.
PDE9A	Phosphodiesterase 9A	0.27	n.s.
PDE10A	Phosphodiesterase 10A	−0.36	n.s.
PDE11A	Phosphodiesterase 11A	−0.81	n.s.
PDE12	Phosphodiesterase 12	−0.01	n.s.

^aLog2FoldChange.

^bAdjusted p values < 0.05 are regarded as statistically significant. *padj < 0.05, **padj < 0.01, ***padj < 0.0001, *****padj < 0.00001.

^cn.s., not significant.

^dn/a, not available.