Table 4.
Top 10 signaling pathways and biological processes in integration analysis.
| Ranking | Pathway | p-value | padj |
|---|---|---|---|
| Reactome (/66) | |||
| 1 | Intracellular signaling by second messengers | 1.81E-08 | 2.40E-05 |
| 2 | Signaling by Interleukins | 4.38E-08 | 2.40E-05 |
| 3 | FLT3 Signaling | 5.35E-08 | 2.40E-05 |
| 4 | MAPK family signaling cascades | 1.92E-07 | 6.46E-05 |
| 5 | MAPK1/MAPK3 signaling | 2.59E-07 | 6.46E-05 |
| 6 | RAF/MAP kinase cascade | 2.88E-07 | 6.46E-05 |
| 7 | Diseases of signal transduction by growth factor receptors and second messengers | 1.47E-06 | 2.82E-04 |
| 8 | Interleukin-37 signaling | 1.71E-06 | 2.88E-04 |
| 9 | PI3K/AKT signaling in cancer | 2.22E-06 | 3.32E-04 |
| 10 | Interleukin-1 family signaling | 3.69E-06 | 4.97E-04 |
| KEGG (/105) | |||
| 1 | PI3K-Akt signaling pathway | 6.54E-13 | 2.05E-10 |
| 2 | Insulin signaling pathway | 2.83E-12 | 4.44E-10 |
| 3 | MAPK signaling pathway | 6.20E-12 | 6.47E-10 |
| 4 | Ras signaling pathway | 8.53E-09 | 6.68E-07 |
| 5 | EGFR tyrosine kinase inhibitor resistance | 3.82E-08 | 2.39E-06 |
| 6 | Focal adhesion | 1.05E-07 | 5.47E-06 |
| 7 | Rap1 signaling pathway | 1.45E-07 | 6.50E-06 |
| 8 | Prostate cancer | 2.17E-07 | 8.49E-06 |
| 9 | cGMP-PKG signaling pathway | 2.77E-07 | 9.62E-06 |
| 10 | Neurotrophin signaling pathway | 5.00E-07 | 1.57E-05 |
| GO-BP (/407) | |||
| 1 | Ras protein signal transduction | 1.72E-13 | 1.03E-09 |
| 2 | Cellular response to peptide | 1.28E-11 | 3.85E-08 |
| 3 | Regulation of small GTPase mediated signal transduction | 2.73E-11 | 5.46E-08 |
| 4 | Response to peptide hormone | 1.24E-10 | 1.86E-07 |
| 5 | Epithelial tube morphogenesis | 6.05E-10 | 7.26E-07 |
| 6 | Rho protein signal transduction | 8.05E-10 | 8.04E-07 |
| 7 | Response to oxygen levels | 1.04E-09 | 8.92E-07 |
| 8 | Regulation of actin filament-based process | 1.20E-09 | 9.02E-07 |
| 9 | Urogenital system development | 1.39E-09 | 9.25E-07 |
| 10 | Response to decreased oxygen levels | 2.03E-09 | 1.22E-06 |