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. 2022 Jun 17;12:914247. doi: 10.3389/fcimb.2022.914247

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Copyright © 2022 Yang, Yang, Zhao, Wang, Li, Jin, Liu, Zhang, Zhang, Zhao, Liao, Li, Hua, Gu, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations of disease-linked microbiota with clinical indicators and bile acids. (A) Heatmap of Spearman correlation coefficients between the fecal microbiome and indicators of liver function. (B) Heatmap of Spearman correlation coefficients between the fecal microbiome and bile acid profiles in BA. Blue and red denote negative and positive correlations, respectively. The depth of the color indicates the correlation between the genus and environmental factors. *p < 0.05, **p < 0.01, ***p < 0.001. ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Chol, cholesterol; DBIL, direct bilirubin; GGT, gamma-glutaryl transferase; GLO, globulin; HDL_C, high-density lipoprotein cholesterol; Hgb, hemoglobin; IBIL, indirect bilirubin; LDL_C, low-density lipoprotein cholesterol; PA, prealbumin; Plt, platelet; RBC, red blood cell; TBA, total bile acid; TBIL, total bilirubin; TG, triglyceride; TP, total protein; VLDL_C, very low-density lipoprotein cholesterol; WBC, white blood cell; 3-DHCA, 3-dehydrocholic acid; 6-ketoLCA, 6-ketolithocholic acid; 7-ketoLCA, 7-ketolithocholic acid; 12-ketoLCA, 12-ketolithocholic acid; βUDCA, 3β-ursodeoxycholic acid; C4, 7a-hydroxy-cholestene-3-one; CA, cholic acid; CDCA, chenodeoxycholic acid; CDCA-3Gln, chenodeoxycholic acid-3-β-D-glucuronide; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholate; GDCA, glycodeoxycholic acid; GHCA, glycohyocholate; GLCA, glycolithocholate; GUDCA, glycoursodeoxycholic acid; HCA, γ-muricholic acid/hyocholic acid; LCA, lithocholic acid; LCA-3S, lithocholic acid 3 sulfate; NorCA, nor cholic acid; TCA, taurocholic acid; TCDCA, taurochenodeoxycholate; TDCA, taurodeoxycholate; TUDCA, tauroursodeoxycholic acid; UDCA, ursodeoxycholic acid.