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. 2022 Jun 17;12:914247. doi: 10.3389/fcimb.2022.914247

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Copyright © 2022 Yang, Yang, Zhao, Wang, Li, Jin, Liu, Zhang, Zhang, Zhao, Liao, Li, Hua, Gu, Wang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fecal microbiota distribution and bile acid profile for patients with jaundice clearance at 6 months after Kasai surgery. Microbiota with significantly different abundances at the family (A) and genus (B) levels between jaundice-clearance and non-jaundice-clearance groups. (C) The volcano plot shows the differential metabolites screened based on a unidimensional statistical analysis. The thresholds in the plot were set as follows: p < 0.05 and between-group variation multiplier, absolute value of FC ≥ 0. (D) Box diagram of different levels of TUDCA between jaundice-clearance and non-jaundice-clearance groups. *p < 0.05, ***p < 0.001. FC, Fold Change; TUDCA, tauroursodeoxycholic acid.