FIGURE 1.

Metformin concentrations following in vivo administration with metformin during pregnancy. N = 10 simultaneously obtained sample trios: maternal plasma, umbilical cord plasma, and placental tissue. (A) Relationship between fetal and maternal plasma metformin concentrations, R² = 0.84, p < 0.001; (B) Relationship between fetal plasma and placental metformin concentrations, R² = 0.97, p < 0.001; (C) Relationship between maternal plasma and placental metformin concentrations, R² = 0.76, p < 0.001.