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. 2022 Apr 22;37(7):1544–1556. doi: 10.1093/humrep/deac082

Figure 2.

Figure 2.

Luciferase reporter assay of the effect of the polymorphism rs10406324 on human AMH promoter activity. −210 A, human AMH promoter construct containing −210 A allele; −210 G, human AMH promoter construct containing −210 G allele; dex, dexamethasone; ESRRA, estrogen-related receptor alpha; GR, glucocorticoid receptor; RLU, relative luciferase unit; SF1, steroidogenic factor 1. Luciferase reporter assay to compare the effect of SF1 in KK1 cells [A], GR with and without stimulation of 5 nM dexamethasone in KK1 cells [B], ESRRA binding in KK1 cells [C] and the effect of SF1 in COV434 cells [D] on the activity of the human AMH promoter containing the −210 A allele and the human AMH promoter containing the −210 G allele. Values are expressed by luminescence rate. P-values were obtained by performing an unpaired t-test. All comparisons between −210 A and −210 G were non-significant (P > 0.05).