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. 2022 Jun 17;10:914120. doi: 10.3389/fcell.2022.914120

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Copyright © 2022 Song, Lou, Ma, Gong, Tian, You, Ren, Guo, Wang, He and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heterogeneity of CAFs in OSCC after ICT. UMAP plot showing the subclusters divided using NMF (A) and the original ident (B). Marker genes expression shown in heatmap. C1 CAFs expressed CXCL12, CXCL14, and IGF1. C2 CAFs expressed CD74 and MHC-Ⅱ. C3 CAFs expressed PDPN and COL1A1 (C). Feature plots showing CXCL12, CXCL14, CD74, HLA-DRA, PDPN, COL1A1 expression in CAFs (D). The proportion of subclusters in residual tumor and tumor bed. C1 CAFs were mainly enriched in tumor bed and C2 and C3 CAFs were enriched in residual tumor (E).