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Heterogeneity of macrophages in OSCC after ICT. UMAP plot showing the subclusters divided using NMF (A) and the original ident (B). Marker genes expression shown in heatmap, highlighting three classic subgroups of TAMs (C2–4). C2 TAMs expressed C1Qs. C3 CAFs expressing FCN1. C4 CAFs expressed SPP1 (C). Feature plots showing C1QC, C1QA, FCN1, SPP1 expression in TAMs (D). The proportion of subclusters in residual tumor and tumor bed (E).
