Figure 5.

Brain MRI lesion evolution in patients with MOGAD, AQP4-IgG+NMOSD, and MS on FLAIR images. [(A,B): MOGAD] Acute bilateral large T2-hyperintensities of middle cerebellar peduncles (right > left) (A₁, arrowheads), and in the thalamus and cortico-spinal tract bilaterally (B₁, arrowheads). All T2-lesions had resolved completely by the time of follow-up MRI (A₂, B₂). [(C D): AQP4-IgG+NMOSD] Acute T2-hyperintense lesion around the 4th ventricle (C₁, arrowhead), resolving to nearly undetectable at follow-up MRI (C₂, arrowhead); and lesions involving the corpus callosum (D₁, arrowheads), undergoing reduction in size without resolution on follow-up MRI (D₂, arrowheads). [(E,F): MS] Acute T2-hyperintense white matter lesions (E₁, F₁, arrowheads), reduced in size but still visible on follow-up MRI (E₂, F₂, arrowheads). MOGAD, myelin oligodendrocyte glycoprotein antibody-associated disease; AQP4-IgG+NMOSD, aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder; MS, multiple sclerosis. FLAIR, fluid attenuated inversion recovery.