Figure 6.

Spinal cord MRI lesion evolution in patients with MOGAD, AQP4-IgG+NMOSD, and MS on T2-images. [(A): MOGAD) A longitudinally extensive T2-hyperintense spinal cord lesion with accompanying spinal cord swelling (A₁, arrowhead) and gray matter involvement (A₂, arrowhead), with complete resolution at follow-up (A₃, sagittal, and A₄, axial view). [(B): AQP4-IgG+NMOSD] A longitudinally extensive T2-hyperintense (B₁, arrowhead), centrally located thoracic spinal cord lesion (B₂, arrowhead). The T2-lesion has substantially reduced in size at follow-up (B₃, arrowhead), with only a mild residual hyperintensity still visible on sagittal view (B₃, arrowhead) and axial view (B₄, arrowhead). [(C): MS] A short T2-hyperintense cervical cord lesion with accompanying spinal cord swelling (C₁, arrowhead) and involving the posterior white matter tracts (C₂, arrowhead), with residual T2-hyperintensity and local atrophy at follow-up (C₃, sagittal view, white arrowhead, and C₄, axial view, arrowhead). At follow-up, the patient also developed a new interval lesion (C₃, green arrowhead). MOGAD, myelin oligodendrocyte glycoprotein antibody-associated disease; AQP4-IgG+NMOSD, aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder; MS, multiple sclerosis.