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. 2022 Jun 17;12:898614. doi: 10.3389/fonc.2022.898614

Figure 3.

Figure 3

Comparison of expression of FOXM1, tumor vascularity, and tumor oxygenation between initial tumors after neoBev and recurrent tumors after neoBev. FOXM1 (A), nestin (B), MVD (C), CA9 (D), and HIF-1α expression (E). Error bar; standard deviation. Kaplan–Meier survival curves showing overall survival stratified by labeling index of FOXM1 expression (p = 0.053, log-rank test) (F), labeling index of nestin expression (p = 0.89, log-rank test) (G), microvascular density (p = 0.43, log-rank test) (H), qualitative reaction of CA9 expression (p = 0.72, log-rank test) (I), and qualitative reaction of HIF-1α expression (p = 0.83, log-rank test) (J). CA9, carbonic anhydrase 9; FOXM1, Forkhead box M1; HIF-1α, hypoxia inducible factor-1 alpha; MVD, microvessel density; neoBev, neoadjuvant bevacizumab.