TABLE 1.

Genomic candidate regions detected by integrated haplotype score (iHS) and cross-population extended haplotype homozygosity (XP-EHH) analysis in the Nguni and Bonsmara population, p < 0.0001.

Biological role	BTA	Gene start a	Gene end a	Gene Name	Reference
iHS nguni
Heat Tolerance	15	53393791	53406519	DNAJB13	Linde (2018)
	19	42257571	42258084	HSPB9	Makina et al. (2015)
	23	17752495	17758156	HSP90AB1	Charoensook et al. (2012)
DNA Methylation	2	95910212	95920426	METTL21A	Jakobsson et al. (2016)
	5	106319032	106389988	PRMT8	Do et al. (2017)
	12	78920744	78929824	METTL21C	Huang et al. (2014)
	13	62142537	62176363	DNMT3B	Guo et al. (2012)
	17	44257597	44259224	MBD3L1	Jin et al. (2008)
Feed efficiency	15	54737997	54748417	SERPINH1	Sun et al. (2019)
	18	51865091	51878472	PLAUR	Sun et al. (2019)
	18	52695747	52724172	RELB	Sun et al. (2019)
Nitrogen Metabolism	5	101041433	101090609	A2ML1	Wang et al. (2021)
	3	23536511	23560620	HMGCS2	Wang et al. (2021)
	18	52637233	52640572	APOE	Wang et al. (2021)
	19	41834618	41840426	KRT17	Wang et al. (2021)
XP-EHH Nguni and Bonsmara
Heat Tolerance	14	30355171	30448182	DNAJC5B	Bhuiyan et al. (2018)
	12	29796159	29819628	HSPH1	Howard et al. (2014)
DNA Methylation	12	35796991	35817783	EEF1AKMT1	Hamey and Wilkins (2018)
Feed Efficiency	14	24365744	24432635	FAM110B	Singh et al. (2020)
	14	24587138	24624435	UBXN2B	Singh et al. (2020)

^aGene start and end position are reported in base pairs (bp).