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. 2022 Jun 8;28(7):gaac022. doi: 10.1093/molehr/gaac022

Figure 1.

Figure 1.

Localization and genomic feature annotation associated with differentially methylated sites (DMS) in case versus control groups. (A) Of the 3679 DMS, 497 were associated with CpG islands (CpGi) (13.5%), 339 were associated with CpG shores (CpGs) (9.2%) and 2843 were not associated with either CpGi or CpGs and deemed CpGother (CpGo) (77.3%). (B) Of the 2214 unique genomic features that the DMS mapped to, 251 were associated with CpGi (10.6%), 210 were associated with CpGs (8.9%) and 1900 were not associated with either and deemed CpGo (80.5%). (C) Stratification of unique genomic feature biotypes of DMS within ±5 kb of the transcription start site. (D) Proportions of DMS in hypo-, hyper-methylated and all DMS associated with specific genic annotation using the ‘annotatr’ package.