Figure 3.

Gene set enrichment analysis of differentially methylated sites (DMS). Gene set enrichment analysis (GSEA) was conducted using g:Profiler-g:GOSt and interrogating KEGG, Reactome and Wikipathways databases. Genesets were considered significant if they had an adjusted P-value (q-value) <0.05 and five or more genes in the gene set. g:SCS multiple testing correction method was used to determine significance. (A) GSEA of all hypomethylated DMS. (B) GSEA of all hypermethylated DMS. A full list of gene sets can be found in Supplementary Tables SII and SIII, respectively.