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. 2022 Jun 30;26(4):255–262. doi: 10.4196/kjpp.2022.26.4.255

Fig. 5. Oxytocin induced vasoconstriction in the unstimulated rat’s aortic rings.

Fig. 5

L-NAME (an inhibitor of nitric oxide synthase) (A) or endothelium removal (B) slightly enhanced oxytocin-induced vasoconstriction; (C) SQ29548 (an inhibitor of prostaglandin H2/thromboxane A2) did not affect oxytocin-induced vasoconstriction; (D) Atosiban completely abolished oxytocin-induced vasoconstriction; (E) PD98059 (an inhibitor of ERK1/2 activation) partially inhibited oxytocin-induced vasoconstriction; (F) Effect of oxytocin on phospho-ERK1/2 expression. OT, oxytocin; Ato, atosiban. n = 8. *p < 0.05 vs. control group, #p < 0.05 vs. oxytocin group.