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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2021 May 14;60(25):14163–14170. doi: 10.1002/anie.202102453

Figure 5.

Figure 5.

Comparative analysis of the bnd biosynthetic gene clusters. Genes are color-coded based upon their annotated Pfam or InterPro designations. The BGCs from the various Streptomyces spp. are almost all identical and are predicted to biosynthesize 1. The BGCs from the two Amycolatopsis spp. and Nocardia sp. SYP-A9097 encode the core genes but possess different genes and genetic organization suggesting they produce the 6,10-bicyclic eunicellane-like core but biosynthesize different natural products.