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. 2022 May 18;109(6):1055–1064. doi: 10.1016/j.ajhg.2022.04.015

Figure 2.

Figure 2

Increasing burden of outlier rare variants is associated with a significant deviation in body mass index and obesity and earlier age of onset for bariatric surgery

(A) Mean BMI across 96,606 UKB individuals binned by IOGC score percentile (gray points). Linear regression fit is displayed in blue. Dashed line indicates cohort average. p value obtained from linear regression.

(B and C) Mean rates of obesity (BMI ≥ 30 kg/m2) (B) and severe obesity (BMI ≥ 40 kg/m2) (C), across deciles of IOGC score. Dashed line indicates cohort averages. Error bars indicate standard error of the mean. p values obtained from logistic regression.

(D) Age at time of bariatric surgery for individuals in top and bottom 10% of IOGC score. Crossbars indicate median, error bars indicate 90% of data range. p value obtained from Wilcoxon test.

(E) Deviation from cohort mean BMI in UKB and MVP as a function of IOGC score decile. p values obtained from linear regression.

(F) Risk for obesity (BMI ≥ 30 kg/m2) in UKB and MVP comparing individuals stratified to top and bottom 10% of IOGC score. Error bars indicate 95% confidence interval. p values obtained from Fisher's exact test.