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. 2022 Jun 17;13:909275. doi: 10.3389/fimmu.2022.909275

Figure 1.

Figure 1

ILCs, their transcription factors, and cytokines. Figure 1 depicts the ILC family, their transcription factors, and cytokines in mice. NK cells are transcription factor T-bet and Eomes dependent cytotoxic ILCs that release cytokines IFN-γ, and TNF together with cytotoxic molecules such as perforin, and granzyme. ILC1-3 and LTis are non-cytotoxic ILCs. ILC1s are dependent on the transcription factors Tbet, NFIL3, and RUNX2 and release IFN-γ, TNF, and IL-4. ILC2s are dependent on the transcription factors RORα, GATA3, Bcl11B, and GFI and release IL-4, IL-5, IL-9, IL-14, and transcription factor Areg. ILC3s are dependent on the transcription factors RORγt, AHR, and ID2 and release TNF, IFN-γ, IL-22, GM-CSF, and IL-17A. LTis are dependent on the transcription factors RORγt, TOX, and ID2 and release IL-17A, GM-CSF, and IL-22. Abbreviations of transcription factors: NFIL3, nuclear factor IL-3 induced; ID2, inhibitor of DNA binding 2; TOX, thymocyte selection associated high mobility group box protein; GATA3, GATA binding protein 3; T-BET, T-box transcription factor; EOMES, Eomesodermin; RUNX3, runt-related transcription factor 3; RORα, RAR-related orphan recepto;, Bcl11b, B cell lymphoma/leukemia 11B; RORγt, RAR- related orphan receptor γt; and AhR, Aryl hydrocarbon receptor. Abbreviations of cytokines: IFN-γ, Interferon-gamma; TNF, Tumor necrosis factor-alpha; IL, Interleukin; GM-CSF, Granulocyte-macrophage colony-stimulating-factor; Areg, amphiregulin.