Figure 3.

Comparison of imputation accuracy in South Asian samples

Imputation accuracy for 762 South Asian samples in UK Biobank data was compared among (1) meta-imputation, (2) imputation using 1000G phase 3 (GRCh38) panel, and (3) imputation using the TOPMed release 2 panel. Aggregated r² value was computed based on 918,144 variants shared by the 1000G panel, the TOPMed panel, and UK Biobank whole-exome-sequencing data. Variants were binned according to minor allele frequency, which was estimated from exome-sequencing data for the 762 samples.