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. 2022 May 3;109(6):1007–1015. doi: 10.1016/j.ajhg.2022.04.002

Figure 4.

Figure 4

Genome-wide summary of weights used in meta-imputation

(A and B) UK Biobank samples were meta-imputed against the 1000G phase 3 panel and the TOPMed release 2 panel. The figures display the local weights on the TOPMed panel from the weight-estimation step, where red indicates a preference for TOPMed and blue indicates a preference for 1000G. (A) corresponds to the analysis of a sample haplotype with South Asian ancestry, where both the 1000G panel and the TOPMed panel were favored in substantial portions of the genome. (B) corresponds to the analysis of a sample haplotype with European ancestry, where the TOPMed panel was nearly always favored.