Figure 1. Flow diagram of the study. Tumor samples from 8 luminal androgen receptor breast cancers underwent Next Generation Sequencing using the FoundationOne Cancer Panel, which interrogates 315 genes as well as introns of 28 genes involved in rearrangements. Twenty-six known genomic alterations (KGAs) and 64 variants of unknown significance (VUS) were identified. Variants of unknown significance were stratified according to their possibly damaging role as indicated by in silico prediction tools. Genes with KGAs, possibly damaging VUS and their combination, which totaled 38 genes as 5 were common between KGA and VUS, were analyzed with functional annotation tools (DAVID and PANTHER) and the results were matched with potential therapeutic targets. *Confirmed implication in breast cancer according to a literature search.